The neurobehavioral mechanisms of motivational control in attention-deficit/hyperactivity disorder.

Journal article

A. Ceceli, J. Y. Natsheh, D. Cruz, Elizabeth Tricomi
Cortex; a journal devoted to the study of the nervous system and behavior, 2020

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APA Click to copy
Ceceli, A., Natsheh, J. Y., Cruz, D., & Tricomi, E. (2020). The neurobehavioral mechanisms of motivational control in attention-deficit/hyperactivity disorder. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior.

Chicago/Turabian Click to copy
Ceceli, A., J. Y. Natsheh, D. Cruz, and Elizabeth Tricomi. “The Neurobehavioral Mechanisms of Motivational Control in Attention-Deficit/Hyperactivity Disorder.” Cortex; a journal devoted to the study of the nervous system and behavior (2020).

MLA Click to copy
Ceceli, A., et al. “The Neurobehavioral Mechanisms of Motivational Control in Attention-Deficit/Hyperactivity Disorder.” Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 2020.

BibTeX Click to copy

@article{a2020a,
  title = {The neurobehavioral mechanisms of motivational control in attention-deficit/hyperactivity disorder.},
  year = {2020},
  journal = {Cortex; a journal devoted to the study of the nervous system and behavior},
  author = {Ceceli, A. and Natsheh, J. Y. and Cruz, D. and Tricomi, Elizabeth}
}

Abstract

Attention-deficit/hyperactivity disorder (ADHD) poses debilitating impairments in the neurobehavioral systems governing reward-related processes-key to the control of motivated behaviors. Individuals with ADHD may rely on a motivational control system that favors cue-driven habits-rooted in the posterior putamen-over caudate and prefrontal cortex-driven goal-directed behaviors. We examined the neurobehavioral correlates of motivational control in ADHD. Twenty-five adults with ADHD and 25 neurotypicals underwent fMRI while training on two stimulus-response-outcome associations. A devaluation procedure followed, whereby they were selectively satiated on one of the snack outcomes, decreasing its value. A subsequent extinction test determined outcome-sensitivity (i.e., whether responses towards devalued snack diminished). Despite behavioral similarities, the ADHD group displayed a distinct neural signature marked by enhanced posterior putamen activation as a function of training. This region also displayed diminished functional connectivity with the dorsal anterior cingulate cortex, which is associated with top-down control. Our whole-brain analysis yielded ADHD-specific posterior putamen and opercular/insular cortex activity over the course of training-regions associated with stimulus-sensitivity and maladaptively rigid behaviors, respectively. Neural comparisons also identified hyper-recruitment of the hippocampus in the ADHD group. These results highlight corticostriatal discrepancies in ADHD, possibly serving as a biomarker of the disorder.